Monoclonal Antibodies for Systemic Lupus Erythematosus (SLE)

Monoclonal Antibodies for Systemic Lupus Erythematosus (SLE) †

A number of monoclonal antibodies (mAb) are now under investigation in clinical trials to assess their potential role in Systemic Lupus Erythematosus (SLE). The most frequently used mAb is rituximab, which is directed against CD20, a membrane protein expressed on B lymphocytes. Uncontrolled trials reported an improvement of SLE activity in non-renal patients and other studies even reported an i...

Anticardiolipin Antibodies in Juvenile Rheumatoid Arthritis and Systemic Lupus Erythematosus

Background: Antiphospholipid antibody syndrome (APS) can either occur as a primary syndrome or associated with other autoimmune diseases such as systemic lupus erythematosus (SLE). Anticardiolipin antibody (aCL) of IgG and/or IgM isotype in blood, measured by a standardized ELISA is the most acceptable laboratory criteria. APS IgG isotype, particularly IgG2 subclass is more strongly associated ...

Neurobrucellosis in systemic lupus erythematosus

Background: Brucellosis is a zoonotic infection which is endemic in many countries. It is a multisystem disease which may present with a broad spectrum of clinical manifestations and complications. Neurobrucellosis is an uncommon complication of brucellosis. Case presentation: A 25-year-old woman with a history of lupus for 5 months referred to the emergency ward of Shahid Beheshti Hosp...

Lupus (Systemic Lupus Erythematosus; SLE) — Diagnosis and Treatment

Mapping of Susceptibility Genes for Systemic Lupus Erythematosus (sle)

Systemic lupus erythematosus (SLE) is an autoimmune disease with variable and diverse clinical manifestations. Its etiology is unclear, but based on epidemiological and animal studies both genetic and environmental factors are involved. Several candidate susceptibility loci have been identified in case-control association studies and in linkage studies (Kelly et al. 2002). Recent genome wide sc...